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I don't think it matters whether anyone thinks the regret is warranted. All that matters is that your sister and her child feel deep regret over not using Carys and it appears they do.

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To answer your other question, I don't particularly like one name over the other. Carys feels less dated than Janine and perhaps that's its chief appeal to your sister. And the situation is fixable. The child can always go by her mn. Lots of people do. Just in my dh's immediate family, there are five people who've done just that. :-)