This name was used only rarely in England during the nineteenth/twentieth century craze for flower names. It received some attention during the 1960s, since it features in Donovan's hit song, "Mellow Yellow". It appears to be used in Turkey as a girl's name, in the form "Safran". In the Bible the spice Saffron - long the most valuable of all spices - is called "karkom"; the modern Hebrew is "safran", like that Turkish girl's name.
Source: Seror, Simon "Les noms des femmes juives en Angleterre au Moyen Âge".