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My vote would be Jessica.

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Its Biblical root, Iscah, is very close to the spelling of Isaac.

This message was edited 5/26/2021, 7:11 PM

Well, there are a number of male names of Hebrew origin, like Joseph and Daniel, who have a female form which consist of the male name plus an extra "a", like Josepha and Daniela.

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So, if you ask people to come up with a female name for Isaac, they will most probably come up with Isaaca, in my opinion.