Thanks for your help all. After doing a search of American birth/death records, we found three instances of Ephrael. All in the same family, all in Pennsylvania, between 1854 and 1910. My guess is that that family (who look to be dutch, from their last name) modified the name from the biblical Ephraim (possibly combining it with Raphael, as PP suggested).
And yes, my husband found it from reading the comic based on the game. Still, I think it's pretty and sounds ligitimate enough. And knowing it's been used before makes me feel better. Thanks for the help all.