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The entry for Custis on page 397 of the Dictionary of American Family Names (2003) written by Patrick Hanks says the following:

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Custis (473) English: unexplained. Possibly from a much altered form of the personal name AUGUSTUS. This is an old VA surname, dating from the 17th century.

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Link to the page in question: https://books.google.de/books?id=FJoDDAAAQBAJ&pg=PA397 (in English).

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Also, you should know that this website has a message board specifically dedicated to surnames, which is better suited for questions like yours. As such, you might perhaps have better luck there. Here it is:

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https://surnames.behindthename.com/bb/sur/

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I hope that helps! :)

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"It is no measure of health to be well-adjusted to a profoundly sick society." ~ Jiddu Krishnamurti (1895-1986)