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The mother of Pope Urban V bore this name.
The name begins appearing in the late 1100s (attested in 1198) with the formal Latin version of Amphelisia and the vernacular version of Anflis.https://en.wikipedia.org/wiki/Royston,_Hertfordshire (Mentioned as a daughter of Richard the Chamberlain)
https://books.google.com/books?id=A7Q_AQAAMAAJ&pg=PA98#v=onepage&q&f=false (bottom of page, Amphelise Dupéage)Variations in the 1200s include Amfelice, Aunphelice, Amphelice, Amyfelyse, Anfelise, Anfelisa, Amfelisia, Amflisia and Aunflis. Later in the 1300s we see Amflis and Amflisa, and it reappears again in the 1600s as Amphelicia and Amphillis.Sources for that? "Possibly a compound of [Amice] and [Felice]."
It's possible it's a compound name; [Felice] / [Felicia] is attested from 1194, and [Amicia] (as [Ames]) from 1189.(Information from name #194642 originally submitted by user LMS)

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