Namesakes
Greek Prime Ministers:
1 prime minister
Spyros Markezinis 1973 
Notable Athletes:
1 track
(track) Spyridon Louis (a.k.a. Spyros) 1873-1940
Olympic Medalists:
1 gold
(gold) Spyridon Louis (a.k.a. Spyros) 1896 marathon
Other Leaders:
1 president
President Spyros Kyprianou 1977-1988 Cyprus