As a given name, it was used on the American sitcom Murphy Brown (1988-1998) for both the mother and son of the main character. By 1998 it was more popular as a name for girls in the United States, perhaps further inspired by a character from the movie Jerry Maguire (1996).
This name was popular throughout the English-speaking world in the early 20th century. It staged a comeback in the early 21st century, returning to the American top ten in 2017.
In the United States this form was much less common than Isabel until the early 1990s, when it began rapidly rising in popularity. It reached a peak in 2009 and 2010, when it was the most popular name for girls in America, an astounding rise over only 20 years.
A famous bearer is the Italian actress Isabella Rossellini (1952-).