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This is the name of one of the main characters in the book series "Roman Mysteries". I therefore have good associations with the name and don't think of the disease and I believe this is true for most kids of my generation as many grew up with the book or TV series. The meaning of "wolf" is nice.
The usage of this name should be changed to "Ancient Roman", because the Romans used Lupus as a cognomen already in the centuries BC - not just in the centuries AD (i.e. after the advent of Christianity). [noted -ed]http://www.trismegistos.org/name/10222 (in English; click on "Attestations by century")
• general search for Lupus at the Epigraphic Database of Heidelberg: https://edh-www.adw.uni-heidelberg.de/inschrift/suche?qs=Lupus (in English)
• Publius Rutilius Lupus (between 18 BC and 12 BC): https://edh-www.adw.uni-heidelberg.de/edh/inschrift/HD031696 (in English)
https://en.wikipedia.org/wiki/List_of_Roman_cognomina#L (in English)
https://en.wikipedia.org/wiki/Lupus_(name) (in English)Note, however, that the cognomen Lupus appears to have been rare in the centuries BC. It only really began to flourish in the centuries AD.A notable bearer of this name was Lucius Cornelius Lentulus Lupus. He was Roman consul in 156 BC and later died in 125 BC:https://en.wikipedia.org/wiki/Lucius_Cornelius_Lentulus_Lupus_(consul_156_BC) (in English)Another notable bearer was Publius Rutilius Lupus, who served as Roman consul in 90 BC:https://en.wikipedia.org/wiki/Publius_Rutilius_Lupus_(consul) (in English)There are many other examples where Lupus is a cognomen, though the majority of them date back to a century AD. Here are some of them:• Cornelius Lupus (42 AD), a Roman senator and suffect consul: https://en.wikipedia.org/wiki/Cornelius_Lupus (in English)
• Curtius Lupus (24 AD), a Roman quaestor: https://en.wikipedia.org/wiki/Curtia_(gens)#Curtii_of_the_Empire (in English)
• Gaius Salvidienus Lupus (era uncertain): https://en.wikipedia.org/wiki/Salvidiena_gens#Undated_Salvidieni (in English)
• Lucius Petilius Lupus (era uncertain): https://en.wikipedia.org/wiki/Petillia_gens#Undated_Petillii (in English)
• Marcus Rutilius Lupus (2nd century AD), a Roman governor of Egypt: https://en.wikipedia.org/wiki/Marcus_Rutilius_Lupus (in English)
• Numisius Lupus (era not clear), a Roman military commander: https://en.wikipedia.org/wiki/Numisia_gens#Members (in English)
• Nymphidius Lupus (1st to 2nd century AD): https://en.wikipedia.org/wiki/Nymphidia_gens#Members (in English)
• Pontius Lupus (era not clear): https://en.wikipedia.org/wiki/Pontia_gens#Members (in English)
• Severius Lupus (era not clear): https://en.wikipedia.org/wiki/Severia_gens#Members (in English)
• Tiberius Julius Lupus (died in 73 AD), a Roman governor of Egypt: https://en.wikipedia.org/wiki/Tiberius_Julius_Lupus (in English)
• Vipsanius Lupus (2nd or 3rd century AD): https://en.wikipedia.org/wiki/Vipsania_gens#Vipsanii_from_inscriptions (in English)
• Virius Lupus (died after 205 AD), a Roman soldier and politician: https://en.wikipedia.org/wiki/Virius_Lupus (in English)
Lupus means "Wolf" in Latin. Or alludes to the wolf, Lupus Constellation.
Just remember, it's never lupus! (line from the TV show House)
Lupus is a disease that affects the skin. This sounds terrible to saddle a child with.
The disease lupus erythematosus does not only affect the skin. It is a chronic inflammatory disease, occurring when the immune system attacks its own tissues and organs.

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