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Masuma Sultan Begum (Persian: معصومہ سلطان بیگم‎; born c. 1508) was a Mughal princess and the daughter of the first Mughal emperor, Babur. She is frequently mentioned in the Humayun-nama by her sister, Gulbadan Begum, who calls her sister 'Elder sister Moon' (mah chacha).
Masuma Esmati-Wardak was an Afghan writer and politician. She was jointly one of the first women to serve in the Afghan parliament and served as Minister of Education. In 1953 she graduated from Kabul Women's College, and received a degree in business in the United States in 1958.
Masuma Sultan Begum (died 1509) was the Queen consort of Ferghana Valley and Samarkand as the fourth wife of Emperor Babur, the founder of the Mughal Empire and the first Mughal emperor. Masuma was a first cousin of her husband and was a Timurid princess by birth. She was the fifth and youngest daughter of Babur's paternal uncle, Sultan Ahmed Mirza, the King of Samarkand and Bukhara.

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