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Ella Sophonisba Hergesheimer (1873 – 1943) was an American illustrator, painter, and printmaker who painted and illustrated Tennessee society, including the state's women and children. As a printmaker, she pioneered the white-line woodcut.
Sophonisba Angusciola (Peale) Sellers (1786 – 1859), known by the nickname "Sopy", was an early American ornithologist and artist. She was also a noted quilt-maker and a surviving example of her work is preserved in the Philadelphia Museum of Art. She is recognized as the first woman in America to collect and prepare bird specimens for scientific study.
She was named after the Italian Renaissance painter, Sophonisba Angusciola (1532–1625).
Sophonisba Preston Breckinridge (1866 – 1948) was an American activist, Progressive Era social reformer, social scientist and innovator in higher education. She was the first woman to earn a Ph.D. in political science and economics then the J.D. at the University of Chicago, and she was the first woman to pass the Kentucky bar. In 1933, President Franklin D. Roosevelt sent her as a delegate to the 7th Pan-American Conference in Uruguay, making her the first woman to represent the U.S. government at an international conference. She led the process of creating the academic professional discipline and degree for social work.
Sofonisba Anguissola (c. 1532 – 1625), also known as Sophonisba Angussola or Sophonisba Anguisciola, was an Italian Renaissance painter born in Cremona to a relatively poor noble family. She received a well-rounded education that included the fine arts, and her apprenticeship with local painters set a precedent for women to be accepted as students of art.As a young woman, Anguissola traveled to Rome where she was introduced to Michelangelo, who immediately recognized her talent, and to Milan, where she painted the Duke of Alba. The Spanish queen, Elizabeth of Valois, was a keen amateur painter and in 1559 Anguissola was recruited to go to Madrid as her tutor, with the rank of lady-in-waiting. She later became an official court painter to the king, Philip II, and adapted her style to the more formal requirements of official portraits for the Spanish court. After the queen's death, Philip helped arrange an aristocratic marriage for her. She moved to Sicily, and later Pisa and Genoa, where she continued to practice as a leading portrait painter.

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