Namesakes
Argentine Presidents:
1 president
Manuel Quintana 1904-1906 
Brazilian Presidents:
2 presidents
Deodoro da Fonseca (a.k.a. Manuel) 1889-1891
Manuel Ferraz de Campos Sales 1898-1902
Fictional Characters from Television:
1 character
Manny Devalos 2005 Medium
French Presidents and Prime Ministers:
1 prime minister
(prime minister) Manuel Valls 2014-2016
Nobel Prize Winners:
1 peace
(peace) Juan Manuel Santos 2016
Notable Actors and Entertainers:
1 actor
Jay Hernandez (middle name Manuel) 1978-
Notable Athletes:
7 soccer, 2 basketball, 1 driving, 1 rugby, 1 tennis
(driving) Juan Manuel Fangio 1911-1995
(soccer) Garrincha (a.k.a. Manuel) 1933-1983
(tennis) Manuel Santana 1938-2021
(basketball) Lolo Sainz 1940-
(basketball) José Calderón (middle name Manuel) 1981-
(soccer) Hélder Postiga (middle name Manuel) 1982-
(soccer) Pepe Reina (middle name Manuel) 1982-
(rugby) Juan Manuel Leguizamón 1983-
(soccer) Silvestre Varela (middle name Manuel) 1985-
(soccer) Manuel Neuer 1986-
(soccer) Nolito (a.k.a. Manuel) 1986-
(soccer) Juan Mata (middle name Manuel) 1988-
Notable Musicians:
3 singers, 1 composer, 1 lyricist/composer, 1 musician
Isaac Albéniz (middle name Manuel) 1860-1909
Bobby Capó (middle name Manuel) 1922-1989
Manny Charlton 1941-2022
Nino Bravo (middle name Manuel) 1944-1973
Lin-Manuel Miranda 1980-
Manuel Turizo 2000-
Notable Writers:
1 playwright
Lin-Manuel Miranda 1980-
Olympic Medalists:
6 bronze, 5 silver, 1 gold, 1 silver/bronze, 1 silver/gold
(silver) Manuel Plaza 1928 marathon
(bronze) Manuel dos Santos 1960 swimming - 100 m freestyle
(bronze) José Manuel Abascal 1984 1500 m
(silver) Juanma López Iturriaga (middle name Manuel) 1984 basketball
(silver) José Manuel Beirán 1984 basketball
(silver) Fernando Romay (middle name Manuel) 1984 basketball
(silver) Manuel Silvestre Sánchez 1992 water polo
(silver/gold) Manuel Estiarte 1992; 1996 water polo
(bronze) Manuel Martínez 2004 shot put
(gold) Manuel Vega 2004 baseball
(bronze) Rui Silva (middle name Manuel) 2004 1500 m
(silver/bronze) José Calderón (middle name Manuel) 2008; 2012; 2016 basketball
(bronze) Manuel Štrlek 2012 handball
(bronze) Jairo Asencio (middle name Manuel) 2020 baseball
Other Leaders:
9 presidents, 1 general secretary, 1 leader
President Manuel Murillo Toro 1864-1866; 1872-1874 Colombia
President Manuel Antonio Sanclemente 1898-1900 Colombia
President José Manuel Marroquín 1900-1904 Colombia
President Manuel L. Quezon 1935-1944 Philippines
President Manuel Ávila Camacho 1940-1946 Mexico
President Manuel Roxas 1946-1948 Philippines
President Manuel Urrutia Lleó 1959 Cuba
Leader Manuel Noriega 1983-1989 Panama
President Juan Manuel Santos 2010-2018 Colombia
General Secretary António Guterres (middle name Manuel) 2017- United Nations
President Andrés Manuel López Obrador 2018-2024 Mexico
Portuguese Kings and Queens:
2 kings
King Manuel I the Fortunate 1495-1521
King Manuel II 1908-1910
Portuguese Presidents and Prime Ministers:
3 prime ministers, 2 presidents, 1 prime minister/president
(president) Manuel de Arriaga 1911-1915
(prime minister) Manuel Maria Coelho 1921
(president) Manuel Teixeira Gomes 1923-1925
(prime minister/president) Manuel Gomes da Costa 1926
(prime minister) António Guterres (middle name Manuel) 1995-2002
(prime minister) José Manuel Barroso 2002-2004
Pulitzer Award Winners:
1 literature
(literature) Lin-Manuel Miranda 2016 Hamilton
Roman and Byzantine Emperors:
2 emperors
Emperor Manuel Comnenus 1143-1180
Emperor Manuel Palaeologus 1391-1425
Saints:
3 blessed, 2 saints
Blessed Emmanuel Ruiz López (a.k.a. Manuel) 1804-1860
Saint Faustino Miguez (a.k.a. Manuel) 1831-1925
Blessed Manuel Domingo y Sol 1836-1909
Saint Manuel González García 1877-1940
Blessed Carlos Manuel Rodríguez Santiago 1918-1963
Spanish Prime Ministers:
5 prime ministers
Manuel Ruiz Zorrilla 1871; 1872-1873
Manuel García Prieto 1917; 1917-1918; 1918; 1922-1923
Manuel Allendesalazar 1919-1920; 1921
Manuel Portela Valladares 1935-1936
Manuel Azaña 1931-1933; 1936