Namesakes
Biblical Characters:
1 character
Isaac (m) Gen. 21:1 
Isaac I 690-692
Dutch Prime Ministers:
1 prime minister
Isaäc Dignus Fransen van de Putte 1866
Emmy Award Winners:
1 actor
(actor) Sid Caesar (a.k.a. Isaac) 1952; 1957 ; Caesar's Hour
Fictional Characters from Movies:
1 character
Ike Godsey (a.k.a. Isaac) 1971 The Homecoming: A Christmas Story
Fictional Characters from Television:
3 characters
Zack Brady (a.k.a. Isaac) 1965 Days of Our Lives
Ike Godsey (a.k.a. Isaac) 1972 The Waltons
Isaac Mendez 2006 Heroes
Hall-of-Famers:
1 football
(football) Isaac Bruce 2020
Hurricanes and Tropical Storms:
4 hurricanes, 1 storm
Storm Isaac 1988
Hurricane Isaac 2000
Hurricane Isaac 2006
Hurricane Isaac 2012
Hurricane Isaac 2018
Nobel Prize Winners:
2 physics, 1 literature
(physics) Isidor Isaac Rabi 1944
(literature) Isaac Bashevis Singer 1978
(physics) Jerome Isaac Friedman 1990
Notable Actors and Actresses:
5 actors, 1 comedian/actor
Chief John Big Tree (a.k.a. Isaac) 1877-1967
Sid Caesar (a.k.a. Isaac) 1922-2014
Jerry Stiller (a.k.a. Isaac) 1927-2020
Liev Schreiber (a.k.a. Isaac) 1967-
Oscar Isaac 1979-
Isaac Hempstead-Wright 1999-
Notable Artists:
1 painter
Isaac Levitan 1860-1900
Notable Athletes:
2 football, 1 rugby, 1 soccer
(football) Isaac Bruce 1972-
(rugby) Isaac Boss 1980-
(soccer) Isaác Brizuela 1990-
(football) Jordan Dangerfield (a.k.a. Isaac) 1990-
Notable Musicians:
2 musicians, 1 composer, 1 musician/singer
Isaac Albéniz 1860-1909 classical
Don Everly (a.k.a. Isaac) 1937-2021
Isaac Hayes 1942-2008 soul
Isaac Hanson 1980- pop, rock
Notable Politicians and Statespeople:
2 politicians
Adolphe Crémieux (a.k.a. Isaac) 1796-1880
Iek Diepenhorst (a.k.a. Isaäc) 1916-2004
Notable Scientists and Inventors:
1 physicist
Isaac Newton 1642-1727
Notable Writers:
1 author
Isaac Asimov 1920-1992
Olympic Medalists:
1 gold
(gold) Isaac Bentham 1912 water polo
Other Leaders:
1 president
President Isaac Herzog 2021- Israel
Rock and Roll Hall-of-Famers:
2 musicians
Don Everly (a.k.a. Isaac) 1986
Isaac Hayes 2002
Roman and Byzantine Emperors:
2 emperors
Emperor Isaac Comnenus 1057-1059
Emperor Isaac Angelus; Isaac II Angelus 1185-1195; 1203-1204
Saints:
3 saints
Saint Isaac of Constantinople ?-410
Saint Isaac of Spoleto ?-550
Saint Isaac of Cordoba 824-851