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I don't know how you would honor those three names in a Biblical way; They aren't Biblical themselves, nor are they related to any Biblical names. The only thing I can think of is that Melissa means honey or honeybee, and so does Deborah, but if I was Melissa and somebody told me they were honoring me by naming their daughter Deborah, I would be totally unimpressed.
My advice is just use those names in the middle name slot, or use the honoree's middle or last or maiden names someplace.

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Isabel Josephine: Way too long and fussy.
Seraphina Karis "Ina" (Karis is Greek for Grace. Would you prefer Seraphina Grace?) Yes, Grace is much simpler and leaves no doubt as to pronunciation. Seraphina Karis just doesn't sound smooth.
Robert Christian "Robin" or "Birdie" Robert Christian is a great combo. Robin and Bertie are dated, overly British nicknames that don't do it justice. Rob, Bobby, even Bert or Chris.
Susannah Jillian Flows nicely. Much prefer Jillian in the first name slot.
Jeshua Nathaniel "Jesse" (Jeshua is a Biblical variant of Joshua) Jeshua may be legit, but it looks like a typo and sounds like a speech impediment. Just name him Jesse Nathaniel, which is very nice. Joshua Nathaniel too, though it's more of a mouthful.

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