From the Greek name Αλεξις (Alexis), which meant "helper" or "defender", derived from Greek αλεξω (alexo) "to defend, to help". This was the name of a 3rd-century BC Greek comic poet, and also of several saints. It is used somewhat interchangeably with the related name Αλεξιος or Alexius, borne by five Byzantine emperors. In the English-speaking world it is more commonly used as a feminine name.

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